Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice

OBJECTIVE: Hypercholesterolemia (HC) and hypertension (HT) are associated with aortic valve stenosis (AVS) in humans. We have examined aortic valve function, structure, and gene expression in HC/HT mice. APPROACH AND RESULTS: Control, hypertensive (HT), hypercholesterolemic (Apoe(−/−)) (HC), and HC/...

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Publicat a:Arterioscler Thromb Vasc Biol
Autors principals: Chu, Yi, Lund, Donald D., Doshi, Hardik, Keen, Henry L., Knudtson, Kevin L., Funk, Nathan D., Shao, Jian Q., Cheng, Justine, Hajj, Georges P., Zimmerman, Kathy A., Davis, Melissa K., Brooks, Robert M., Chapleau, Mark W., Sigmund, Curt D., Weiss, Robert M., Heistad, Donald D.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767592/
https://ncbi.nlm.nih.gov/pubmed/26769049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306912
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