Differential regulation of interferon responses by Ebola and Marburg virus VP35 proteins

Suppression of innate immune responses during filoviral infection contributes to disease severity. Ebola (EBOV) and Marburg (MARV) viruses each encode a VP35 protein that suppresses RIG-I-like receptor signaling and interferon-α/β (IFN-α/β) production by several mechanisms, including direct binding...

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Vydáno v:Cell Rep
Hlavní autoři: Edwards, Megan R., Liu, Gai, Mire, Chad E., Sureshchandra, Suhas, Luthra, Priya, Yen, Benjamin, Shabman, Reed S., Leung, Daisy W., Messaoudi, Ilhem, Geisbert, Thomas W., Amarasinghe, Gaya K., Basler, Christopher F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767585/
https://ncbi.nlm.nih.gov/pubmed/26876165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.049
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