Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT can also activate RIG-I. To counteract innate antiviral responses, some viruses, including Ebola virus (EBOV), encode pr...

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Main Authors: Luthra, Priya, Ramanan, Parameshwaran, Mire, Chad E., Weisend, Carla, Tsuda, Yoshimi, Yen, Benjamin, Liu, Gai, Leung, Daisy W., Geisbert, Thomas W., Ebihara, Hideki, Amarasinghe, Gaya K., Basler, Christopher F.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875338/
https://ncbi.nlm.nih.gov/pubmed/23870315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2013.06.010
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