2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations

Previous structure-activity relationship studies indicate that a series of cocaine analogs, 3β-aryltropanes with 2β-diarylmethoxy substituents, selectively bind to the dopamine transporter (DAT) with nanomolar affinities that are 10-fold greater than the affinities of their corresponding 2α-enantiom...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Pharmacol Exp Ther
Auteurs principaux: Hong, Weimin C., Kopajtic, Theresa A., Xu, Lifen, Lomenzo, Stacey A., Jean, Bernandie, Madura, Jeffry D., Surratt, Christopher K., Trudell, Mark L., Katz, Jonathan L.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2016
Sujets:
Neuropharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767397/
https://ncbi.nlm.nih.gov/pubmed/26769919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.230722
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