Dopamine Transporter-Dependent and -Independent Striatal Binding of the Benztropine Analog JHW 007, a Cocaine Antagonist with Low Abuse Liability

The benztropine analog N-(n-butyl)-3α-[bis(4′-fluorophenyl)methoxy]-tropane (JHW 007) displays high affinity for the dopamine transporter (DAT), but unlike typical DAT ligands, has relatively low abuse liability and blocks the effects of cocaine, including its self-administration. To determine sites...

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Detalhes bibliográficos
Main Authors: Kopajtic, Theresa A., Liu, Yi, Surratt, Christopher K., Donovan, David M., Newman, Amy H., Katz, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202473/
https://ncbi.nlm.nih.gov/pubmed/20855444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.171629
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