Preclinical Efficacy of N-Substituted Benztropine Analogs as Antagonists of Methamphetamine Self-Administration in Rats

Atypical dopamine-uptake inhibitors have low abuse potential and may serve as leads for development of cocaine-abuse treatments. Among them, the benztropine (BZT) derivatives, N-butyl (JHW007), N-allyl (AHN2-005), and N-methyl (AHN1-055) analogs of 3α-[bis(4′-fluorophenyl)methoxy]-tropane dose-depen...

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Autores principales: Hiranita, Takato, Kohut, Stephen J., Soto, Paul L., Tanda, Gianluigi, Kopajtic, Theresa A., Katz, Jonathan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2014
Materias:
Behavioral Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868882/
https://ncbi.nlm.nih.gov/pubmed/24194527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208264
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