Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects

Atypical dopamine transporter (DAT) inhibitors, despite high DAT affinity, do not produce the psychomotor stimulant and abuse profile of standard DAT inhibitors such as cocaine. Proposed contributing features for those differences include off-target actions, slow onsets of action, and ligand bias re...

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Hong, Weimin C., Wasko, Michael J., Wilkinson, Derek S., Hiranita, Takato, Li, Libin, Hayashi, Shuichiro, Snell, David B., Madura, Jeffry D., Surratt, Christopher K., Katz, Jonathan L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2018
Matèries:
Neuropharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102189/
https://ncbi.nlm.nih.gov/pubmed/29945932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.250498
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