Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects

Atypical dopamine transporter (DAT) inhibitors, despite high DAT affinity, do not produce the psychomotor stimulant and abuse profile of standard DAT inhibitors such as cocaine. Proposed contributing features for those differences include off-target actions, slow onsets of action, and ligand bias re...

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書目詳細資料
發表在:J Pharmacol Exp Ther
Main Authors: Hong, Weimin C., Wasko, Michael J., Wilkinson, Derek S., Hiranita, Takato, Li, Libin, Hayashi, Shuichiro, Snell, David B., Madura, Jeffry D., Surratt, Christopher K., Katz, Jonathan L.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2018
主題:
Neuropharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102189/
https://ncbi.nlm.nih.gov/pubmed/29945932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.250498
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