Acidic pH increases airway surface liquid viscosity in cystic fibrosis

Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection, inflammation, and mucus accumulation to progressively destroy the lungs. Our previous studies revealed that mucus with abnormal behavior impaired mucociliary transport in newborn CF piglets prior to the onset of s...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Tang, Xiao Xiao, Ostedgaard, Lynda S., Hoegger, Mark J., Moninger, Thomas O., Karp, Philip H., McMenimen, James D., Choudhury, Biswa, Varki, Ajit, Stoltz, David A., Welsh, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767348/
https://ncbi.nlm.nih.gov/pubmed/26808501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83922
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