Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

BACKGROUND: Aberrant Hedgehog (Hh) signaling is associated with the development of many cancers including prostate cancer, gastrointestinal cancer, lung cancer, pancreatic cancer, ovarian cancer, and basal cell carcinoma. The Hh signaling pathway has been one of the most intensely investigated targe...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Cancer
Main Authors: Alam, Md Maksudul, Sohoni, Sagar, Kalainayakan, Sarada Preeta, Garrossian, Massoud, Zhang, Li
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766751/
https://ncbi.nlm.nih.gov/pubmed/26911235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2200-x
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