CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts

Cataracts are the leading cause of vision loss in the world, although surgical treatment can restore vision in cataract patients. Until now, there have been no adequate animal models for in vivo studies of artificial lens safety and drug interactions. Genetic studies have demonstrated that GJA8 is i...

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Published in:Sci Rep
Main Authors: Yuan, Lin, Sui, Tingting, Chen, Mao, Deng, Jichao, Huang, Yongye, Zeng, Jian, Lv, Qingyan, Song, Yuning, Li, Zhanjun, Lai, Liangxue
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766569/
https://ncbi.nlm.nih.gov/pubmed/26912477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22024
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