CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts

Cataracts are the leading cause of vision loss in the world, although surgical treatment can restore vision in cataract patients. Until now, there have been no adequate animal models for in vivo studies of artificial lens safety and drug interactions. Genetic studies have demonstrated that GJA8 is i...

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Vydáno v:Sci Rep
Hlavní autoři: Yuan, Lin, Sui, Tingting, Chen, Mao, Deng, Jichao, Huang, Yongye, Zeng, Jian, Lv, Qingyan, Song, Yuning, Li, Zhanjun, Lai, Liangxue
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766569/
https://ncbi.nlm.nih.gov/pubmed/26912477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22024
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