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Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

Tissue fibrosis contributes to nearly half of all deaths in the developed world and is characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models are mechanically static. Here, we used visible light-mediated stiffening hydrogels to investigate cell mechanotransd...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Caliari, Steven R., Perepelyuk, Maryna, Cosgrove, Brian D., Tsai, Shannon J., Lee, Gi Yun, Mauck, Robert L., Wells, Rebecca G., Burdick, Jason A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764908/
https://ncbi.nlm.nih.gov/pubmed/26906177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21387
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