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Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

Tissue fibrosis contributes to nearly half of all deaths in the developed world and is characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models are mechanically static. Here, we used visible light-mediated stiffening hydrogels to investigate cell mechanotransd...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Caliari, Steven R., Perepelyuk, Maryna, Cosgrove, Brian D., Tsai, Shannon J., Lee, Gi Yun, Mauck, Robert L., Wells, Rebecca G., Burdick, Jason A.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764908/
https://ncbi.nlm.nih.gov/pubmed/26906177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21387
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