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Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

Tissue fibrosis contributes to nearly half of all deaths in the developed world and is characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models are mechanically static. Here, we used visible light-mediated stiffening hydrogels to investigate cell mechanotransd...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Caliari, Steven R., Perepelyuk, Maryna, Cosgrove, Brian D., Tsai, Shannon J., Lee, Gi Yun, Mauck, Robert L., Wells, Rebecca G., Burdick, Jason A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764908/
https://ncbi.nlm.nih.gov/pubmed/26906177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21387
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