Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility

Approximately 25–30% of colorectal cancer (CRC) cases are expected to result from a genetic predisposition, but in only 5–10% of these cases highly penetrant germline mutations are found. The remaining CRC heritability is still unexplained, and may be caused by a hitherto-undefined set of rare varia...

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Publicat a:PLoS Genet
Autors principals: de Voer, Richarda M., Hahn, Marc-Manuel, Weren, Robbert D. A., Mensenkamp, Arjen R., Gilissen, Christian, van Zelst-Stams, Wendy A., Spruijt, Liesbeth, Kets, C. Marleen, Zhang, Junxiao, Venselaar, Hanka, Vreede, Lilian, Schubert, Nil, Tychon, Marloes, Derks, Ronny, Schackert, Hans K., Geurts van Kessel, Ad, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J. L., Kuiper, Roland P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764646/
https://ncbi.nlm.nih.gov/pubmed/26901136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005880
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