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Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility

Approximately 25–30% of colorectal cancer (CRC) cases are expected to result from a genetic predisposition, but in only 5–10% of these cases highly penetrant germline mutations are found. The remaining CRC heritability is still unexplained, and may be caused by a hitherto-undefined set of rare varia...

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Vydáno v:PLoS Genet
Hlavní autoři: de Voer, Richarda M., Hahn, Marc-Manuel, Weren, Robbert D. A., Mensenkamp, Arjen R., Gilissen, Christian, van Zelst-Stams, Wendy A., Spruijt, Liesbeth, Kets, C. Marleen, Zhang, Junxiao, Venselaar, Hanka, Vreede, Lilian, Schubert, Nil, Tychon, Marloes, Derks, Ronny, Schackert, Hans K., Geurts van Kessel, Ad, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J. L., Kuiper, Roland P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764646/
https://ncbi.nlm.nih.gov/pubmed/26901136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005880
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