Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility

Approximately 25–30% of colorectal cancer (CRC) cases are expected to result from a genetic predisposition, but in only 5–10% of these cases highly penetrant germline mutations are found. The remaining CRC heritability is still unexplained, and may be caused by a hitherto-undefined set of rare varia...

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Pubblicato in:PLoS Genet
Autori principali: de Voer, Richarda M., Hahn, Marc-Manuel, Weren, Robbert D. A., Mensenkamp, Arjen R., Gilissen, Christian, van Zelst-Stams, Wendy A., Spruijt, Liesbeth, Kets, C. Marleen, Zhang, Junxiao, Venselaar, Hanka, Vreede, Lilian, Schubert, Nil, Tychon, Marloes, Derks, Ronny, Schackert, Hans K., Geurts van Kessel, Ad, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J. L., Kuiper, Roland P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764646/
https://ncbi.nlm.nih.gov/pubmed/26901136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005880
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