Selective Allosteric Antibodies to the Insulin Receptor for the Treatment of Hyperglycemic and Hypoglycemic Disorders

Many therapeutic monoclonal antibodies act as antagonists to receptors by targeting and blocking the natural ligand binding site (orthosteric site). In contrast, the use of antibodies to target receptors at allosteric sites (distinct from the orthosteric site) has not been extensively studied. This...

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Dettagli Bibliografici
Pubblicato in:J Diabetes Sci Technol
Autori principali: Issafras, Hassan, Bedinger, Daniel H., Corbin, John A., Goldfine, Ira D., Bhaskar, Vinay, White, Mark L., Rubin, Paul, Scannon, Patrick J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2014
Soggetti:
Review Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764207/
https://ncbi.nlm.nih.gov/pubmed/24876415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1932296814529886
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