Selective Allosteric Antibodies to the Insulin Receptor for the Treatment of Hyperglycemic and Hypoglycemic Disorders

Many therapeutic monoclonal antibodies act as antagonists to receptors by targeting and blocking the natural ligand binding site (orthosteric site). In contrast, the use of antibodies to target receptors at allosteric sites (distinct from the orthosteric site) has not been extensively studied. This...

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Detalhes bibliográficos
Publicado no:J Diabetes Sci Technol
Main Authors: Issafras, Hassan, Bedinger, Daniel H., Corbin, John A., Goldfine, Ira D., Bhaskar, Vinay, White, Mark L., Rubin, Paul, Scannon, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2014
Assuntos:
Review Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764207/
https://ncbi.nlm.nih.gov/pubmed/24876415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1932296814529886
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