Selective Allosteric Antibodies to the Insulin Receptor for the Treatment of Hyperglycemic and Hypoglycemic Disorders

Many therapeutic monoclonal antibodies act as antagonists to receptors by targeting and blocking the natural ligand binding site (orthosteric site). In contrast, the use of antibodies to target receptors at allosteric sites (distinct from the orthosteric site) has not been extensively studied. This...

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Détails bibliographiques
Publié dans:J Diabetes Sci Technol
Auteurs principaux: Issafras, Hassan, Bedinger, Daniel H., Corbin, John A., Goldfine, Ira D., Bhaskar, Vinay, White, Mark L., Rubin, Paul, Scannon, Patrick J.
Format: Artigo
Langue:Inglês
Publié: SAGE Publications 2014
Sujets:
Review Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764207/
https://ncbi.nlm.nih.gov/pubmed/24876415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1932296814529886
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