Selective Allosteric Antibodies to the Insulin Receptor for the Treatment of Hyperglycemic and Hypoglycemic Disorders

Many therapeutic monoclonal antibodies act as antagonists to receptors by targeting and blocking the natural ligand binding site (orthosteric site). In contrast, the use of antibodies to target receptors at allosteric sites (distinct from the orthosteric site) has not been extensively studied. This...

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Publicado en:J Diabetes Sci Technol
Autores principales: Issafras, Hassan, Bedinger, Daniel H., Corbin, John A., Goldfine, Ira D., Bhaskar, Vinay, White, Mark L., Rubin, Paul, Scannon, Patrick J.
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publications 2014
Materias:
Review Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764207/
https://ncbi.nlm.nih.gov/pubmed/24876415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1932296814529886
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