A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1(−/−) mouse model of KATP hyperinsulinism

Loss-of-function mutations of the ß-cell ATP-sensitive potassium channels (K(ATP)) cause the most common and severe form of congenital hyperinsulinism (K(ATP)HI), a disorder of ß-cell function characterized by severe hypoglycemia. Children with K(ATP)HI are typically unresponsive to medical therapy...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Patel, Puja, Charles, Lawrenshey, Corbin, John, Goldfine, Ira D., Johnson, Kirk, Rubin, Paul, De León, Diva D.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150619/
https://ncbi.nlm.nih.gov/pubmed/29589989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1457599
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