A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

Many patients with diabetes mellitus (both type 1 and type 2) require therapy to maintain normal fasting glucose levels. To develop a novel treatment for these individuals, we used phage display technology to target the insulin receptor (INSR) complexed with insulin and identified a high affinity, a...

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Hlavní autoři: Bhaskar, Vinay, Goldfine, Ira D., Bedinger, Daniel H., Lau, Angela, Kuan, Hua F., Gross, Lisa M., Handa, Masahisa, Maddux, Betty A., Watson, Susan R., Zhu, Shirley, Narasimha, Ajay J., Levy, Raphael, Webster, Lynn, Wijesuriya, Sujeewa D., Liu, Naichi, Wu, Xiaorong, Chemla-Vogel, David, Tran, Catarina, Lee, Steve R., Wong, Steve, Wilcock, Diane, White, Mark L., Corbin, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Pharmacology and Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331746/
https://ncbi.nlm.nih.gov/pubmed/22403294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1578
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