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α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease

α-Synuclein (α-syn) has been implicated in neurological disorders with parkinsonism, including Parkinson's disease and Dementia with Lewy body. Recent studies have shown α-syn oligomers released from neurons can propagate from cell-to-cell in a prion-like fashion exacerbating neurodegeneration....

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Dettagli Bibliografici
Pubblicato in:Hum Mol Genet
Autori principali: Spencer, Brian, Kim, Changyoun, Gonzalez, Tania, Bisquertt, Alejandro, Patrick, Christina, Rockenstein, Edward, Adame, Anthony, Lee, Seung-Jae, Desplats, Paula, Masliah, Eliezer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764192/
https://ncbi.nlm.nih.gov/pubmed/26740557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv633
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