ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo

Parkinson's disease and dementia with Lewy bodies are neurodegenerative disorders characterized by accumulation of α-synuclein (α-syn). Recently, single-chain fragment variables (scFVs) have been developed against individual conformational species of α-syn. Unlike more traditional monoclonal an...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Spencer, Brian, Emadi, Sharareh, Desplats, Paula, Eleuteri, Simona, Michael, Sarah, Kosberg, Kori, Shen, Jay, Rockenstein, Edward, Patrick, Christina, Adame, Anthony, Gonzalez, Tania, Sierks, Michael, Masliah, Eliezer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428402/
https://ncbi.nlm.nih.gov/pubmed/25008355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.129
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