Reversible centriole depletion with an inhibitor of Polo-like kinase 4

Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing centers of animal cells. Extra centrosomes are a common feature of cancer cells. To investigate the importance of centrosomes in the proliferation of normal and cancer cells, we developed centrinone, a reversi...

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Pubblicato in:Science
Autori principali: Wong, Yao Liang, Anzola, John V., Davis, Robert L., Yoon, Michelle, Motamedi, Amir, Kroll, Ashley, Seo, Chanmee P., Hsia, Judy E., Kim, Sun K., Mitchell, Jennifer W., Mitchell, Brian J., Desai, Arshad, Gahman, Timothy C., Shiau, Andrew K., Oegema, Karen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764081/
https://ncbi.nlm.nih.gov/pubmed/25931445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5111
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