Reversible centriole depletion with an inhibitor of Polo-like kinase 4

Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing centers of animal cells. Extra centrosomes are a common feature of cancer cells. To investigate the importance of centrosomes in the proliferation of normal and cancer cells, we developed centrinone, a reversi...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Wong, Yao Liang, Anzola, John V., Davis, Robert L., Yoon, Michelle, Motamedi, Amir, Kroll, Ashley, Seo, Chanmee P., Hsia, Judy E., Kim, Sun K., Mitchell, Jennifer W., Mitchell, Brian J., Desai, Arshad, Gahman, Timothy C., Shiau, Andrew K., Oegema, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764081/
https://ncbi.nlm.nih.gov/pubmed/25931445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5111
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