Direct Binding of SAS-6 to ZYG-1 Recruits SAS-6 to the Mother Centriole for Cartwheel Assembly

Assembly of SAS-6 dimers to form the centriolar cartwheel requires the ZYG-1/Plk4 kinase. Here we show that ZYG-1 recruits SAS-6 to the mother centriole independently of its kinase activity; kinase activity is subsequently required for cartwheel assembly. We identify a direct interaction between ZYG...

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Main Authors: Lettman, Molly M., Wong, Yao Liang, Viscardi, Valeria, Niessen, Sherry, Chen, Sheng-hong, Shiau, Andrew K., Zhou, Huilin, Desai, Arshad, Oegema, Karen
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655416/
https://ncbi.nlm.nih.gov/pubmed/23673331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.03.011
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