Structural basis underlying a novel mechanism for control of receptor tyrosine kinase signal selectivity

SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites. However, the modest binding affinity of SH2 domains to pY cont...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Bae, Jae Hyun, Lew, Erin Denise, Yuzawa, Satoru, Tome, Francisco, Lax, Irit, Schlessinger, Joseph
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764080/
https://ncbi.nlm.nih.gov/pubmed/19665973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.028
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