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Structural basis underlying a novel mechanism for control of receptor tyrosine kinase signal selectivity
SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites. However, the modest binding affinity of SH2 domains to pY cont...
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| Опубликовано в: : | Cell |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4764080/ https://ncbi.nlm.nih.gov/pubmed/19665973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.028 |
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