Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models

ABSTRACT: Huntington’s disease (HD) is a genetic disease caused by a CAG trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin (HTT) protein, ultimately leading to neuronal loss and consequent cognitive decline and death. As no treatments for HD currently exist, several che...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Smalley, Joshua L., Breda, Carlo, Mason, Robert P., Kooner, Gurdeep, Luthi-Carter, Ruth, Gant, Timothy W., Giorgini, Flaviano
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762922/
https://ncbi.nlm.nih.gov/pubmed/26428929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-015-1344-5
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