Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

BACKGROUND: The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the cir...

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Veröffentlicht in:N Engl J Med
Hauptverfasser: Neafsey, D.E., Juraska, M., Bedford, T., Benkeser, D., Valim, C., Griggs, A., Lievens, M., Abdulla, S., Adjei, S., Agbenyega, T., Agnandji, S.T., Aide, P., Anderson, S., Ansong, D., Aponte, J.J., Asante, K.P., Bejon, P., Birkett, A.J., Bruls, M., Connolly, K.M., D’Alessandro, U., Dobaño, C., Gesase, S., Greenwood, B., Grimsby, J., Tinto, H., Hamel, M.J., Hoffman, I., Kamthunzi, P., Kariuki, S., Kremsner, P.G., Leach, A., Lell, B., Lennon, N.J., Lusingu, J., Marsh, K., Martinson, F., Molel, J.T., Moss, E.L., Njuguna, P., Ockenhouse, C.F., Ogutu, B. Ragama, Otieno, W., Otieno, L., Otieno, K., Owusu-Agyei, S., Park, D.J., Pellé, K., Robbins, D., Russ, C., Ryan, E.M., Sacarlal, J., Sogoloff, B., Sorgho, H., Tanner, M., Theander, T., Valea, I., Volkman, S.K., Yu, Q., Lapierre, D., Birren, B.W., Gilbert, P.B., Wirth, D.F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762279/
https://ncbi.nlm.nih.gov/pubmed/26488565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1505819
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