Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

BACKGROUND: The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the cir...

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Dades bibliogràfiques
Publicat a:N Engl J Med
Autors principals: Neafsey, D.E., Juraska, M., Bedford, T., Benkeser, D., Valim, C., Griggs, A., Lievens, M., Abdulla, S., Adjei, S., Agbenyega, T., Agnandji, S.T., Aide, P., Anderson, S., Ansong, D., Aponte, J.J., Asante, K.P., Bejon, P., Birkett, A.J., Bruls, M., Connolly, K.M., D’Alessandro, U., Dobaño, C., Gesase, S., Greenwood, B., Grimsby, J., Tinto, H., Hamel, M.J., Hoffman, I., Kamthunzi, P., Kariuki, S., Kremsner, P.G., Leach, A., Lell, B., Lennon, N.J., Lusingu, J., Marsh, K., Martinson, F., Molel, J.T., Moss, E.L., Njuguna, P., Ockenhouse, C.F., Ogutu, B. Ragama, Otieno, W., Otieno, L., Otieno, K., Owusu-Agyei, S., Park, D.J., Pellé, K., Robbins, D., Russ, C., Ryan, E.M., Sacarlal, J., Sogoloff, B., Sorgho, H., Tanner, M., Theander, T., Valea, I., Volkman, S.K., Yu, Q., Lapierre, D., Birren, B.W., Gilbert, P.B., Wirth, D.F.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762279/
https://ncbi.nlm.nih.gov/pubmed/26488565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1505819
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