Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

BACKGROUND: The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporozoite antibody titres and the magnitude and duration of vaccine efficacy using d...

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Опубликовано в: :Lancet Infect Dis
Главные авторы: White, Michael T, Verity, Robert, Griffin, Jamie T, Asante, Kwaku Poku, Owusu-Agyei, Seth, Greenwood, Brian, Drakeley, Chris, Gesase, Samwel, Lusingu, John, Ansong, Daniel, Adjei, Samuel, Agbenyega, Tsiri, Ogutu, Bernhards, Otieno, Lucas, Otieno, Walter, Agnandji, Selidji T, Lell, Bertrand, Kremsner, Peter, Hoffman, Irving, Martinson, Francis, Kamthunzu, Portia, Tinto, Halidou, Valea, Innocent, Sorgho, Hermann, Oneko, Martina, Otieno, Kephas, Hamel, Mary J, Salim, Nahya, Mtoro, Ali, Abdulla, Salim, Aide, Pedro, Sacarlal, Jahit, Aponte, John J, Njuguna, Patricia, Marsh, Kevin, Bejon, Philip, Riley, Eleanor M, Ghani, Azra C
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier Science ;, The Lancet Pub. Group 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655306/
https://ncbi.nlm.nih.gov/pubmed/26342424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(15)00239-X
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