Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

BACKGROUND: The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporozoite antibody titres and the magnitude and duration of vaccine efficacy using d...

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Pubblicato in:Lancet Infect Dis
Autori principali: White, Michael T, Verity, Robert, Griffin, Jamie T, Asante, Kwaku Poku, Owusu-Agyei, Seth, Greenwood, Brian, Drakeley, Chris, Gesase, Samwel, Lusingu, John, Ansong, Daniel, Adjei, Samuel, Agbenyega, Tsiri, Ogutu, Bernhards, Otieno, Lucas, Otieno, Walter, Agnandji, Selidji T, Lell, Bertrand, Kremsner, Peter, Hoffman, Irving, Martinson, Francis, Kamthunzu, Portia, Tinto, Halidou, Valea, Innocent, Sorgho, Hermann, Oneko, Martina, Otieno, Kephas, Hamel, Mary J, Salim, Nahya, Mtoro, Ali, Abdulla, Salim, Aide, Pedro, Sacarlal, Jahit, Aponte, John J, Njuguna, Patricia, Marsh, Kevin, Bejon, Philip, Riley, Eleanor M, Ghani, Azra C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science ;, The Lancet Pub. Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655306/
https://ncbi.nlm.nih.gov/pubmed/26342424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(15)00239-X
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