Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

BACKGROUND: The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the cir...

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Publicado en:N Engl J Med
Autores principales: Neafsey, D.E., Juraska, M., Bedford, T., Benkeser, D., Valim, C., Griggs, A., Lievens, M., Abdulla, S., Adjei, S., Agbenyega, T., Agnandji, S.T., Aide, P., Anderson, S., Ansong, D., Aponte, J.J., Asante, K.P., Bejon, P., Birkett, A.J., Bruls, M., Connolly, K.M., D’Alessandro, U., Dobaño, C., Gesase, S., Greenwood, B., Grimsby, J., Tinto, H., Hamel, M.J., Hoffman, I., Kamthunzi, P., Kariuki, S., Kremsner, P.G., Leach, A., Lell, B., Lennon, N.J., Lusingu, J., Marsh, K., Martinson, F., Molel, J.T., Moss, E.L., Njuguna, P., Ockenhouse, C.F., Ogutu, B. Ragama, Otieno, W., Otieno, L., Otieno, K., Owusu-Agyei, S., Park, D.J., Pellé, K., Robbins, D., Russ, C., Ryan, E.M., Sacarlal, J., Sogoloff, B., Sorgho, H., Tanner, M., Theander, T., Valea, I., Volkman, S.K., Yu, Q., Lapierre, D., Birren, B.W., Gilbert, P.B., Wirth, D.F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762279/
https://ncbi.nlm.nih.gov/pubmed/26488565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1505819
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