Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)(1–6). Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders(7), suggesting that SCs play a causative role in certain age-related pathol...

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Publicado no:Nat Med
Main Authors: Chang, Jianhui, Wang, Yingying, Shao, Lijian, Laberge, Remi-Martin, Demaria, Marco, Campisi, Judith, Janakiraman, Krishnamurthy, Sharpless, Norman E, Ding, Sheng, Feng, Wei, Luo, Yi, Wang, Xiaoyan, Aykin-Burns, Nukhet, Krager, Kimberly, Ponnappan, Usha, Hauer-Jensen, Martin, Meng, Aimin, Zhou, Daohong
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762215/
https://ncbi.nlm.nih.gov/pubmed/26657143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4010
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