Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

PURPOSE: Ionizing radiation (IR)einduced pulmonary fibrosis (PF) is an irreversible and severe late effect of thoracic radiation therapy. The goal of this study was to determine whether clearance of senescent cells with ABT-263, a senolytic drug that can selectively kill senescent cells, can reverse...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Pan, Jin, Li, Deguan, Xu, Yanfeng, Zhang, Junling, Wang, Yueying, Chen, Mengyi, Lin, Shuai, Huang, Lan, Chung, Eun Joo, Citrin, Deborah E., Wang, Yingying, Hauer-Jensen, Martin, Zhou, Daohong, Meng, Aimin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853175/
https://ncbi.nlm.nih.gov/pubmed/28479002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2017.02.216
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados