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Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids

Recombinant adeno-associated virus vectors (rAAV) are being explored as gene delivery vehicles for the treatment of various inherited and acquired disorders. rAAVs are attractive vectors for several reasons: wild-type AAVs are nonpathogenic, and rAAVs can trigger long-term transgene expression even...

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Vydáno v:Hum Gene Ther Methods
Hlavní autoři: Chamberlain, Kyle, Riyad, Jalish Mahmud, Weber, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761816/
https://ncbi.nlm.nih.gov/pubmed/26757051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2015.140
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