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Impact of Capsid Conformation and Rep-Capsid Interactions on Adeno-Associated Virus Type 2 Genome Packaging

Single-stranded genomes of adeno-associated virus (AAV) are packaged into preformed capsids. It has been proposed that packaging is initiated by interaction of genome-bound Rep proteins to the capsid, thereby targeting the genome to the portal of encapsidation. Here we describe a panel of mutants wi...

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Bibliografische gegevens
Hoofdauteurs: Bleker, Svenja, Pawlita, Michael, Kleinschmidt, Jürgen A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2006
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346863/
https://ncbi.nlm.nih.gov/pubmed/16378983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.2.810-820.2006
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