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Mutational Analysis of Narrow Pores at the Fivefold Symmetry Axes of Adeno-Associated Virus Type 2 Capsids Reveals a Dual Role in Genome Packaging and Activation of Phospholipase A2 Activity

Adeno-associated virus type 2 (AAV2) capsids show 12 pores at the fivefold axes of symmetry. We mutated amino acids which constitute these pores to investigate possible functions of these structures within the AAV2 life cycle. Mutants with alterations in conserved residues were impaired mainly in ge...

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Bibliografische gegevens
Hoofdauteurs: Bleker, Svenja, Sonntag, Florian, Kleinschmidt, Jürgen A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2005
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC546590/
https://ncbi.nlm.nih.gov/pubmed/15681453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.4.2528-2540.2005
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