Identification of a Heparin-Binding Motif on Adeno-Associated Virus Type 2 Capsids

Infection of cells with adeno-associated virus (AAV) type 2 (AAV-2) is mediated by binding to heparan sulfate proteoglycan and can be competed by heparin. Mutational analysis of AAV-2 capsid proteins showed that a group of basic amino acids (arginines 484, 487, 585, and 588 and lysine 532) contribut...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Kern, A., Schmidt, K., Leder, C., Müller, O. J., Wobus, C. E., Bettinger, K., Von der Lieth, C. W., King, J. A., Kleinschmidt, J. A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Structure and Assembly
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC224995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14512555/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.20.11072-11081.2003
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