Optimization of the capsid of recombinant adeno-associated virus 2 (AAV2) vectors: the final threshold?
The ubiquitin-proteasome pathway plays a critical role in the intracellular trafficking of AAV2 vectors, and phosphorylation of certain surface-exposed amino acid residues on the capsid provides the primary signal for ubiquitination. Removal of several critical tyrosine (Y) and serine (S) residues o...
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| Huvudupphov: | , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Public Library of Science (PLoS)
2013-01-01
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| Serie: | PLoS ONE |
| Länkar: | http://europepmc.org/articles/PMC3602601?pdf=render |
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