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Physiologically Based Modelling of Darunavir/Ritonavir Pharmacokinetics During Pregnancy

Pregnant women are usually excluded from clinical trials. Physiologically based pharmacokinetic (PBPK) modelling may provide a method to predict pharmacokinetics in pregnant women, without the need to perform extensive in vivo clinical trials. Here, we used mechanistic modelling to delineate the pot...

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Bibliografski detalji
Izdano u:Clin Pharmacokinet
Glavni autori: Colbers, Angela, Greupink, Rick, Litjens, Carlijn, Burger, David, Russel, Frans G. M.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761019/
https://ncbi.nlm.nih.gov/pubmed/26369773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0325-8
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