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Physiologically-Based Pharmacokinetic Modeling for Predicting the Effect of Intrinsic and Extrinsic Factors on Darunavir or Lopinavir Exposure Co-administered with Ritonavir
Management of comorbidities and medications is complex in HIV-1 infected patients. The overall objective of this project was to develop separate physiologically-based pharmacokinetic (PBPK) substrate models for the protease inhibitors darunavir and lopinavir. These protease inhibitors are used in th...
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| Publicado no: | J Clin Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5591066/ https://ncbi.nlm.nih.gov/pubmed/28569994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.936 |
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