Sequential activation and distinct functions for distal and proximal modules within the IgH 3′ regulatory region

As a master regulator of functional Ig heavy chain (IgH) expression, the IgH 3′ regulatory region (3′RR) controls multiple transcription events at various stages of B-cell ontogeny, from newly formed B cells until the ultimate plasma cell stage. The IgH 3′RR plays a pivotal role in early B-cell rece...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Garot, Armand, Marquet, Marie, Saintamand, Alexis, Bender, Sébastien, Le Noir, Sandrine, Rouaud, Pauline, Carrion, Claire, Oruc, Zéliha, Bébin, Anne-Gaëlle, Moreau, Jeanne, Lebrigand, Kevin, Denizot, Yves, Alt, Frederick W., Cogné, Michel, Pinaud, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760834/
https://ncbi.nlm.nih.gov/pubmed/26831080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514090113
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