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C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation

Mutations in genes encoding myosin, the molecular motor that powers cardiac muscle contraction, and its accessory protein, cardiac myosin binding protein C (cMyBP-C), are the two most common causes of hypertrophic cardiomyopathy (HCM). Recent studies established that the N-terminal domains (NTDs) of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Harris, Samantha P., Belknap, Betty, Van Sciver, Robert E., White, Howard D., Galkin, Vitold E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760775/
https://ncbi.nlm.nih.gov/pubmed/26831109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518891113
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