Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding

The rates at which domains fold and codons are translated are important factors in determining whether a nascent protein will co-translationally fold and function or misfold and malfunction. Here we develop a chemical kinetic model that calculates a protein domain's co-translational folding cur...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Nissley, Daniel A., Sharma, Ajeet K., Ahmed, Nabeel, Friedrich, Ulrike A., Kramer, Günter, Bukau, Bernd, O'Brien, Edward P.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759629/
https://ncbi.nlm.nih.gov/pubmed/26887592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10341
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items