A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data

Analysis methods based on simulations and optimization have been previously developed to estimate relative translation rates from next-generation sequencing data. Translation involves molecules and chemical reactions, hence bioinformatics methods consistent with the laws of chemistry and physics are...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Sharma, Ajeet K., Sormanni, Pietro, Ahmed, Nabeel, Ciryam, Prajwal, Friedrich, Ulrike A., Kramer, Günter, O’Brien, Edward P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559674/
https://ncbi.nlm.nih.gov/pubmed/31120880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007070
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