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Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination
Monocytes and macrophages are critical for the effectiveness of monoclonal antibody therapy. Responses to antibody-coated tumor cells are largely mediated by Fcγ receptors (FcγRs), which become activated upon binding to immune complexes. FcγRIIb is an inhibitory FcγR that negatively regulates these...
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出版年: | J Biol Chem |
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主要な著者: | , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
American Society for Biochemistry and Molecular Biology
2016
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4759169/ https://ncbi.nlm.nih.gov/pubmed/26694610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701151 |
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