Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination

Monocytes and macrophages are critical for the effectiveness of monoclonal antibody therapy. Responses to antibody-coated tumor cells are largely mediated by Fcγ receptors (FcγRs), which become activated upon binding to immune complexes. FcγRIIb is an inhibitory FcγR that negatively regulates these...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Fatehchand, Kavin, Ren, Li, Elavazhagan, Saranya, Fang, Huiqing, Mo, Xiaokui, Vasilakos, John P., Dietsch, Gregory N., Hershberg, Robert M., Tridandapani, Susheela, Butchar, Jonathan P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759169/
https://ncbi.nlm.nih.gov/pubmed/26694610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701151
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