Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination

Monocytes and macrophages are critical for the effectiveness of monoclonal antibody therapy. Responses to antibody-coated tumor cells are largely mediated by Fcγ receptors (FcγRs), which become activated upon binding to immune complexes. FcγRIIb is an inhibitory FcγR that negatively regulates these...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Fatehchand, Kavin, Ren, Li, Elavazhagan, Saranya, Fang, Huiqing, Mo, Xiaokui, Vasilakos, John P., Dietsch, Gregory N., Hershberg, Robert M., Tridandapani, Susheela, Butchar, Jonathan P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2016
विषय:
Immunology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759169/
https://ncbi.nlm.nih.gov/pubmed/26694610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701151
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