Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination

Monocytes and macrophages are critical for the effectiveness of monoclonal antibody therapy. Responses to antibody-coated tumor cells are largely mediated by Fcγ receptors (FcγRs), which become activated upon binding to immune complexes. FcγRIIb is an inhibitory FcγR that negatively regulates these...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Fatehchand, Kavin, Ren, Li, Elavazhagan, Saranya, Fang, Huiqing, Mo, Xiaokui, Vasilakos, John P., Dietsch, Gregory N., Hershberg, Robert M., Tridandapani, Susheela, Butchar, Jonathan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759169/
https://ncbi.nlm.nih.gov/pubmed/26694610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701151
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